Gavin Coombes and Craig Casey both start for Ireland for the first time this weekend while Fineen Wycherley is in line to make his debut if sprung from the bench.
Caelan Doris switches to the blindside flank to accommodate Coombes at No.8 with the uncapped Nick Timoney at openside.
James Ryan wears the captainโs armband and is partnered in the second row by Ryan Baird.
In the front row Tom OโToole is set to make his international debut alongside Ronan Kelleher and Dave Kilcoyne.
The half-back partnership sees Casey join provincial colleague Joey Carbery.
Stuart McCloskey retains the inside centre berth and is joined by fellow Ulsterman debutant James Hume. Hugo Keenan starts his 13th consecutive game at fullback with Andrew Conway and the uncapped Robert Baloucoune on the wings.
The replacements include Dave Heffernan, Ed Byrne, Finlay Bealham, Will Addison and the uncapped Fineen Wycherley, Paul Boyle, Caolin Blade and Harry Byrne.
Ireland team to play USA โ 10th July 2021, Aviva Stadium
15. Hugo Keenan (Leinster/UCD) 12 caps
14. Robert Baloucoune (Ulster/Enniskillen) uncapped
13. James Hume (Ulster/Banbridge) uncapped
12. Stuart McCloskey (Ulster/Bangor) 5 caps
11. Andrew Conway (Munster/Garryowen) 24 caps
10. Joey Carbery (Munster/Clontarf) 23 caps
9. Craig Casey (Munster/Shannon) 2 caps
1. Dave Kilcoyne (Munster/UL Bohemians) 44 caps
2. Ronan Kelleher (Leinster/Lansdowne) 12 caps
3. Tom OโToole (Ulster/Ballynahinch) uncapped
4. Ryan Baird (Leinster/Dublin University) 4 caps
5. James Ryan (Leinster/UCD) 36 caps captain
6. Caelan Doris (Leinster/St Maryโs College) 8 caps
7. Nick Timoney (Ulster/Banbridge) uncapped
8. Gavin Coombes (Munster/Young Munster) 1 cap
Replacements
16. Dave Heffernan (Connacht/Buccaneers) 5 caps
17. Ed Byrne (Leinster/UCD) 5 caps
18. Finlay Bealham (Connacht/Buccaneers) 15 caps
19. Fineen Wycherley (Munster/Young Munster) uncapped
20. Paul Boyle (Connacht/Buccaneers) uncapped
21. Caolin Blade (Connacht/Galwegians) uncapped
22. Harry Byrne (Leinster/Lansdowne) uncapped
23. Will Addison (Ulster/Enniskillen) 4 caps
The match will be televised by RTE (ROI) Channel 4 (NI) and kicks off at 7.15pm.