There are five debutants in the starting XV while a further seven players could make their Munster debuts from the bench.
12 players are set to make their senior Munster debuts with eight members of the Greencore Munster Rugby Academy included.
There are five debutants in the starting XV with Academy quartet Patrick Campbell, Scott Buckley, Eoin O’Connor, and Daniel Okeke and Senior prop James French all set for their first start in the red of Munster.
There are first starts of the season in red for Conor Murray, Damian de Allende and Chris Farrell with the latter making his 50th Munster appearance after returning from an abdomen injury.
Campbell starts at full-back with Andrew Conway and Keith Earls on either flank.
De Allende and Farrell team up in the centres with Murray and Joey Carbery in the half-backs.
Dave Kilcoyne packs down in the front row with Buckley and French.
Tadhg Beirne starts alongside O’Connor in the second row as captain Peter O’Mahony, John Hodnett and Okeke complete the side.
Hodnett has recovered from a short-term ankle injury to make his first start in 13 months, and his Champions Cup debut, having missed the majority of last season with an achilles injury.
Roman Salanoa is among the replacements having recovered from a knee injury with seven players in line to make their Munster debuts off the bench.
Summer addition Declan Moore and Academy quartet Mark Donnelly, Ethan Coughlan, Tony Butlerand and Jonathan Wren are all included.
Also named are Cork Constitution’s John Forde, a product of PBC and member of the Provincial Talent Squad, and Young Munster’s Conor Moloney, a member of the National Talent Squad.
Moloney came up through the ranks at Ennis RFC in the same team as Coughlan and Butler with the trio lining out for the Ennis RFC U18s as recently as last year.
Munster: Patrick Campbell; Andrew Conway, Chris Farrell, Damian de Allende, Keith Earls; Joey Carbery, Conor Murray; Dave Kilcoyne, Scott Buckley, James French; Eoin O’Connor, Tadhg Beirne; Peter O’Mahony (C), John Hodnett, Daniel Okeke.
Replacements: Declan Moore, Mark Donnelly, Roman Salanoa, John Forde, Conor Moloney, Ethan Coughlan, Tony Butler, Jonathan Wren.