Investec Champions Cup
Coombes joined Munster in 2018 and has gone on to make 91 appearances. He has also featured twice for Andy Farrell’s Ireland side.
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The half-back and centre partnerships are unchanged as Craig Casey, Jack Crowley, Alex Nankivell and Antoine Frisch keep their places.
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EPCR confirmed the dates, venues, kick-off times and TV coverage of all Round of 16 fixtures on Thursday, with every tie set to be televised.
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Despite the loss, Munster did secure their passage into the Round of 16 due to the losing bonus point picked up.
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There is one change to the side that beat Toulon in France last week as Oli Jager starts at tighthead prop after completing the return to play protocols.
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Munster had to come from 10-0 behind in the opening half but went into the interval with a 17-13 lead, with the game developing into a tough contest.
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Full-back Simon Zebo and wingers Calvin Nash and Shane Daly line out together in an unchanged back three.
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